HaoRan Biofermentation Tank: Advantages and Application Areas


Smart Chip Control, Steadfast Reliability: The Core Advantages of Haoran Fermentation Tanks
Ultimate cleanliness and full-process sterility guaranteed: Haoran products utilize an integrated CNC polishing process to deeply treat the internal cavities, achieving an exceptionally high surface finish of Ra ≤ 0.1–0.4 μm (EP-grade) across all material-contact surfaces within the tank—effectively eliminating even the tiniest crevices and dead spots where contaminants could accumulate. The tank lid incorporates a quick-release clamp system along with a robust triple-seal sterile closure mechanism, while critical interfaces such as manholes, sight glasses, and feed-in connections are designed with hygienic fluid dynamics in mind. Additionally, the system supports seamless integration of both Steam-In-Place (SIP) sterilization and Clean-In-Place (CIP) cleaning processes, enabling a fully closed-loop operation—from media preparation and high-temperature sterilization to batch discharge—all without interruption.
Precision Environmental Parameter Control Expert:
Precise and Efficient Oxygen Transfer: Equipped with a variable-speed, multi-stage flat/sloped impeller system, this setup supports both cantilever shaft and bottom magnetic levitation shaft configurations. Paired with a ring-shaped jet distributor, it enables precise dissolved oxygen (DO) gradient control, maintaining DO saturation accuracy within an error range of ±0.5 ppm.
Highly stable temperature control: Integrating a jacketed coil design with a variable-frequency cooling medium regulation module, this system employs a multi-point thermosensor network to collaboratively maintain temperature fluctuations within ±0.3°C. Additionally, it features a pre-installed interface for a cryogenic liquid nitrogen nozzle, ensuring compatibility with extreme low-temperature fermentation requirements.
Precise pH Control & Automatic Defoaming: The imported acid metering pump and peristaltic alkali pump precisely adjust based on real-time biosensor data; meanwhile, a high-speed laser foam monitoring probe is integrated with a high-pressure defoaming agent injection valve to instantly eliminate foam interference.
Intelligent Monitoring Module Integration: The device is equipped with an IoT edge processing terminal, offering full compatibility with OPC-UA and Modbus-TCP protocols. It can dynamically collect and analyze key real-time curves, including DO, temperature, pH, tank pressure, and feed rate. Optionally, it can be fitted with a high-definition endoscopic panoramic camera system to monitor mycelial growth and floc conditions inside the tank, with AI-powered capabilities for predicting abnormal behaviors. Additionally, all operational logs can be stored and exported in JSON format, enabling GMP-compliant production traceability audits.
Empowering multiple industries: Precisely driving the industrialization of biotechnology
Food and Seasoning Brewing Upgrade:

Domestic large-scale seasoning manufacturers are using Haoran's customized 10-ton fully automatic yeast propagation tanks, achieving a 12% increase in fermentation efficiency.
Southwest region soy sauce producers have replaced the traditional large-cylinder brewing process with a 120㎡ array of fiber-optic bioreactors, reducing the production cycle by 30% and cutting off-the-beat alcohol generation by 40%.
Breakthrough in the biopharmaceutical field:

A certain gene-recombinant protein drug CDMO utilizes a 100-liter Haoran bioreactor for high-throughput expansion of the master cell bank, increasing the cell density in the reactor from OD600 = 120 to OD600 = 240.
Vaccine companies have deployed Haoran tank cluster-based deep-microcarrier formulations, successfully achieving high-efficiency Vero cell expansion.
Microbial formulation companies have successfully addressed the risk of Bacillus phage contamination by implementing a modular, high-density microencapsulation fermentation system.
Green Manufacturing of Bio-based Materials:

The bio-PHA production project utilizes Haoran’s high-pressure air-agitated aerobic fermentation tanks (operating pressure ≥1.2 MPa), effectively addressing the challenge of insufficient polymer chain extension.
A certain environmental technology company has built an anaerobic ammonia oxidation system using Haoran tanks to treat landfill leachate, achieving an ammonia nitrogen degradation rate of 98.5% and realizing the resourceful utilization of industrial wastewater.
Agricultural Bio-fermentation Upgrade:

A large-scale biofertilizer manufacturer uses a 5-group parallel Haoran deep-liquid fermentation platform to culture and propagate live bacteria, increasing the probiotic survival rate to 10¹¹ CFU/g.
The high-end organic agriculture park utilizes a micro-scale plant growth hormone fermentation system for the precise fermentation production of crop biostimulants.